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Document Type |
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Thesis |
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Document Title |
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HETEROAROMATIC PYROZOLE BASED POLYMERS THROUGH POLYCONDENSATION TECHNIQUE. SYNTHESIS AND APPLICATIONS بوليمرات البيرازول الحلقية الأروماتيه الجديدة باستخدام تقنية بلمرة التكاثف. التخليق والتطبيقات |
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Subject |
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Faculty of Science |
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Document Language |
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Arabic |
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Abstract |
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The work described in this thesis has been classified into three objectives. The first part aims to synthesize four novel series of polyazomethine based on the pyrazole moiety using the polycondensation technique for biological interests. The polymerization occurred through the interaction between terephthalaldehyde and various derivatives of diaminopyrazole. The resultant polymers were given the abbreviation PAZm/Py1-4 according to the different diaminopyrazole derivatives used. The monomer and polymer structures were investigated by spectral common characterization methods. The new PAZm/Py1-4 were examined by gel permeation chromatography GPC, Thermogravimetric Analysis (TGA), solubility tests, Scanning Electron Microscopy (SEM), and X-ray Diffraction Analysis (XRD). The newly synthesized polymers have high thermal stability and normal crystalline behavior. Gram-positive and Gram-negative bacteria were used to test the antibacterial efficacy of each synthesized polymer. Additionally, two types of fungi were used to test how well the prepared polymers worked against fungi. PAZm/Py1 and PAZm/Py4 showed slight antibacterial activity against the representative Gram-positive bacteria, while PAZm/Py2 and PAZm/Py3 had no significant influence. All the tested polymers showed slight to moderate antibacterial activity against the representative Gram-negative bacteria. PAZm/Py1 and PAZm/Py4 had a greater antifungal influence than other polymers. The second part is to synthesize as well as characterize another group of new polyazomethine based on the pyrazole moiety and containing Cl substitution in various positions (ortho, meta, and para) and their nanocomposites (PAZm/Py4-6 and PAZm/Py/ZnOa-c) throughout the polycondensation technique. The new polyazomethines were classified as promising antimicrobial products. Finally, the third part aimed to fabricate another class of aromatic polyazomethine nanocomposites (PAZm/Py/MWCNTsa-c) based on the pyrazole moiety through the polycondensation technique with ultrasonic assistance. The produced polymer nanocomposites were identified by IR spectroscopy and characterized by common characterization tools including TGA, XRD, SEM, and TEM. All tested polymer nanocomposites possessed variable antibacterial and antifungal activity against the selected bacteria and fungi.
Key words:(biologically active, polyazomethine, pyrazole, synthesis, nanocomposites) |
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Supervisor |
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Dr. Hajer Saeed Alorfi |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1445 AH
2023 AD |
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Co-Supervisor |
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Prof. Mahmoud A. Hussein |
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Added Date |
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Tuesday, October 3, 2023 |
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Researchers
| عقيلة أحمد حكمي | Hakami, Aqilah Ahmed | Researcher | Master | |
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