Document Details

Document Type : Thesis 
Document Title :
Retooling immunoadhesins as trap receptor to treat and prevent coronavirus infection
مستقبلات خادعة للحماية ومعالجة العدوي الفيروسية
 
Subject : Faculty of Nursing 
Document Language : Arabic 
Abstract : The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the Middle East respiratory syndrome coronavirus (MERS-CoV) are highly pathogenic human coronaviruses (CoVs). Anti-CoVs mAbs and vaccines may be effective, but the emergence of neutralization escape variants is inevitable. Angiotensin-converting enzyme 2 (ACE2) and dipeptidyl peptidase 4 enzyme (DPP4) are the getaway receptors for SARS-CoV-2 and MERS-CoV, respectively. We tested recombinant ACE2-Fc and DPP4-Fc decoy receptors in parallel with mAbs against several pseudotyped SARS-CoV-2 variants and MERS-CoV. The generated Fc-based decoy receptors exhibited strong inhibitory effect against all pseudotyped CoVs. The generated data also showed that although mAbs can be effective antiviral drugs, yet they might rapidly lose their efficacy against highly mutated viruses, as shown against some of the SARS-CoV-2 variants. Thus, we suggest that receptor traps can be engineered as Fc-fusion proteins for highly mutated viruses with known entry receptors, for a faster and more effective therapeutic response even against virus harboring antibodies escape mutations. 
Supervisor : Dr. Mohamed Ahmed Alfaleh 
Thesis Type : Master Thesis 
Publishing Year : 1444 AH
2023 AD 
Added Date : Wednesday, August 9, 2023 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رامي خلف الخالديAlkhaldi, Rami KhalafResearcherMaster 

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 49281.pdf pdf 

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