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Document Type |
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Thesis |
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Document Title |
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VINPOCETINE-LOADED NANOSIZED EMULSOMES FOR BRAIN TARGETING جسيمات مستحلبة محملة بعقار الفينبوسيتين لتحسين التوصيل إلى المخ |
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Subject |
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faculty of Pharmacy |
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Document Language |
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Arabic |
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Abstract |
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Vinpocetine (VIN) is used orally for the treatment of cerebrovascular disorders such as Alzheimer’s disease by improving the blood flow of the brain. However, the clinical use of VIN is limited due to its poor water solubility, short half-life, as well as extensive first pass-metabolism that lead to low oral bioavailability and reduced brain levels. This work aimed at exploring the potential of intranasal emulsomes for enhancing brain delivery of VIN. VIN emulsomes were prepared by modified thin-film hydration technique. 32 21 full factorial design was applied to investigate the effect of independent variables namely; phospholipid: solid lipid (X1), phospholipid: cholesterol (X2), and solid lipid type (X3) on vesicular size (Y1), zeta potential (Y2), entrapment efficiency (Y3), and release efficiency after 24 h (Y4). Optimized VIN emulsomes (3:1 X1, 2:1 X2, tristearin X3) showed spherical shape nanoparticles with vesicle size of 329.50 nm, zeta potential of -48.50 mV, entrapment efficiency of 78%, and controlled drug release. The optimized formulation was further subjected to surface modification via cationization and PEGylation to improve passage across blood brain barrier. In vivo study revealed significantly higher brain levels of VIN emulsomes, cationic emulsomes, and PEGylated emulsomes compared to the oral market product. Accordingly, VIN intranasal emulsomes could be regarded as a promising alternative for orally administered formulation with improved bioavailability and enhanced brain levels. |
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Supervisor |
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Dr. Shaimaa M. Badr-Eldin |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1442 AH
2021 AD |
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Co-Supervisor |
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Prof. Hibah M. Al-Dawsari |
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Added Date |
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Wednesday, July 7, 2021 |
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Researchers
| نورة يوسف عسيري | Assiri, Nourah Youssef | Researcher | Master | |
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