Document Details

Document Type : Thesis 
Document Title :
RELATIONSHIP BETWEEN SUBCLINICAL ATHEROSCLEROSIS AND POLYCYSTIC SYNDROME (PCOS) COMPONENTS IN YOUNG FEMALES
العلاقة مابين تصلب الشرايين التاجية المبكر ومتلازمة تكيس المبايض لدى الاناث الشابات
 
Subject : Faculty of Medicine 
Document Language : Arabic 
Abstract : Background and Aim: PCOS is a pro-inflammatory condition associated with markers of chronic inflammation implicated in metabolic disturbances, central obesity and menstrual irregularities, which characterize this disorder. It represents the most common cause for young women to be at high risk for the development of atherosclerosis. Atherosclerosis is a systemic process, which is characterized by chronic inflammation. Higher serum levels of tumor necrosis factor alpha and interleukin-6 in women with PCOS have been associated with early carotid atherosclerotic changes. The association between subclinical atherosclerosis and PCOS components in young Saudi female has not been adequately investigated. Thus, we aimed to evaluate TNF-α and IL-6 as early inflammatory biomarkers for subclinical atherosclerosis in young Saudi women with PCOS. Methods: Case-control study included 200 female subjects (aged between18 to 40) were matched by age and recruited from the Obstetrics and Gynecology Clinics at King Abdulaziz University Hospital and King Abdulaziz Hospital at Jeddah, Saudi Arabia. PCOS condition was diagnosed using the Rotterdam criteria. Demographic, dietary and lifestyle variables were collected by a questionnaire from all study subjects. Anthropometric and blood pressure measurements were taken. Biochemical parameters including TNF-α and IL-6 levels were determined for all participants. Results: Serum TNF-α and IL-6 levels were significantly higher in PCOS cases compared with controls group (p<0.001, p<0.05, respectively). Significant positive association between IL-6 and hs-CRP (r=0.172, P= 0.014) and an inverse correlation between TNF-α and hs-CRP (r=- 0.160, p= 0.002) were observed. Moreover, highly significant positive correlation was reported between TNF-α and IL-6 (r= 0.223, P=0.001). Conclusion: Women with PCOS have altered circulatory levels of inflammatory cardiovascular risk markers (e.g.,) TNF-α and IL-6, which are mainly attributable to the accumulation of visceral fat and an effect of insulin resistance. Future longitudinal studies are necessary to clarify pathogenetic mechanisms, which link chronic inflammation and atherosclerosis in PCOS. 
Supervisor : Prof. Eman Mokbel Alissa 
Thesis Type : Master Thesis 
Publishing Year : 1440 AH
2019 AD 
Added Date : Wednesday, September 11, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سامية عبدالله القرنيAl-Garni, Samiah AbdullahResearcherMaster 

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