Document Details

Document Type : Article In Journal 
Document Title :
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
KIF2A regulates the development of dentate granule cells and postnatal hippocampal wiring
 
Document Language : English 
Abstract : Kinesin super family protein 2A (KIF2A), an ATP-dependent microtubule (MT) destabilizer, regulates cell migration, axon elongation, and pruning in the developing nervous system. KIF2A mutations have recently been identified in patients with malformed cortical development. However, postnatal KIF2A is continuously expressed in the hippocampus, in which new neurons are generated throughout an individual's life in established neuronal circuits. In this study, we investigated KIF2A function in the postnatal hippocampus by using tamoxifen-inducible Kif2a conditional knockout (Kif2a-cKO) mice. Despite exhibiting no significant defects in neuronal proliferation or migration, Kif2a-cKO mice showed signs of an epileptic hippocampus. In addition to mossy fiber sprouting, the Kif2a-cKO dentate granule cells (DGCs) showed dendro-axonal conversion, leading to the growth of many aberrant overextended dendrites that eventually developed axonal properties. These results suggested that postnatal KIF2A is a key length regulator of DGC developing neurites and is involved in the establishment of precise postnatal hippocampal wiring. 
ISSN : 2050-084X 
Journal Name : eLife 
Volume : 7 
Issue Number : 1 
Publishing Year : 1439 AH
2018 AD 
Article Type : Article 
Added Date : Sunday, June 23, 2019 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Noriko HommaHomma, Noriko ResearcherDoctorate 
Ruyun ZhouZhou, Ruyun ResearcherDoctorate 
Muhammad Imran NaseerNaseer, Muhammad ImranResearcherDoctorate 
Adeel G ChaudharyChaudhary, Adeel GResearcherDoctorate 
Mohammed H Al-QahtaniAl-Qahtani, Mohammed HResearcherDoctorate 
Nobutaka HirokawaHirokawa, Nobutaka InvestigatorDoctoratehirokawa@m.u-tokyo.ac.jp

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