Document Details

Document Type : Article In Journal 
Document Title :
High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma
High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma
 
Document Language : English 
Abstract : AIM: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) and determine its prognostic potential. PATIENTS & METHODS: CRC samples of 127 patients were studied. Protein expressions of MMP-2, -7 and -9 were analyzed by immunohistochemistry and association with clinicopathological variables was statistically analyzed. RESULTS: Overexpressions of MMP-2 and MMP-9 correlated with poor outcome as evaluated by univariate Kaplan-Meier for disease-free survival (p = 0.04, p = 0.0001) and disease-specific survival (p = 0.01, p = 0.01), respectively. Cox analysis of MMP-2 and -9 were significant independent predictors of disease-free survival (p = 0.006, p = 0.018) and disease-specific survival (p = 0.004, p = 0.049), respectively. CONCLUSION: MMPs expression patterns provide useful prognostic information in CRC, while predicting the patients at high risk for recurrent disease. 
ISSN : 1479-6694 
Journal Name : Future Oncology 
Volume : 12 
Issue Number : 3 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Monday, May 2, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Nada SalemSalem, Nada Investigator  
Ibrahim KamalKamal, Ibrahim Researcher  
Jaudah Al-MaghrabiAl-Maghrabi, Jaudah Researcher  
Adel AbuzenadahAbuzenadah, Adel Researcher  
Abdul Ali Peer-ZadaPeer-Zada, Abdul Ali Researcher  
Yousif QariQari, Yousif Researcher  
Mahmoud Al-AhwalAl-Ahwal, Mahmoud Researcher  
Mohammed Al-QahtaniAl-Qahtani, Mohammed Researcher  
Abdelbaset BuhmeidaBuhmeida, Abdelbaset Researcher  

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