Document Details

Document Type : Article In Journal 
Document Title :
Rituximab for refractory cases of childhood nephrotic syndrome
ريتوكسيماب للحالات الغير مستجيبة للعلاج من المتلازمة الكلوية عند الأطفال
 
Subject : Hereditary Disorders 
Document Language : English 
Abstract : Rituximab has been used over the last decade as a rescue therapy for refractory cases of nephrotic syndrome (NS). Here we report the use of rituximab in four children with idiopathic steroid-resistant nephrotic syndrome (SRNS) with various histological backgrounds (two cases with focal segmental glomerulosclerosis, one case with IgM nephropathy, and one case with minimal change disease), who failed to respond to other immunsuppressions. Their median age (range) was 10 (8–11) years. NPHS2 genetic mutation was negative in all of them. All patients received a single dose of rituximab (375 mg/m2) and achieved complete B cell depletion as CD19 was <1% for 3 months following rituximab infusion. Only one patient achieved non-sustained remission as he relapsed after 4 months despite zero CD19 level. Patients received no further doses of rituximab as B cell was depleted in the peripheral circulation. We conclude that a single dose of rituximab was not effective in inducing sustained remission in children with idiopathic SRNS, despite complete B cell depletion in the peripheral circulation. Further doses might be indicated to deplete non-circulating B cells. 
ISSN : 1432-198X 
Journal Name : Pediatric Nephrology 
Volume : 26 
Issue Number : 5 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Monday, May 30, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
جميلة قاريQari, Jameela InvestigatorDoctorate 

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