Document Details

Document Type : Thesis 
Document Title :
The Use of Dry Lemon as an Appetite Enhancer in Relation to Kidney Structure and Function of Male Rats
استخدام الليمون الجاف كمادة مكسبه للشهية وعلاقته بتركيب ووظيفة كلى ذكور الجرذان
 
Subject : Faculty of Science 
Document Language : Arabic 
Abstract : The contamination of food and feedstuff with mycotoxins represents worldwide problem for both humans and animals. Citrinin, one of the well known mycotoxins, which was first isolated from Penicillium citrinum, is produced by more than 10 species of fungi, and is possibly spread all over the world. However, the information on the mode of toxin action is limited. Citrinin has been suggested as a causative factor in renal disease and death among livestock, poultry and perhaps humans as well since it is commonly found in food samples. Nephrotoxicity is produced in swine by feeding grain contaminated with P. citrinum. This study deals with the effect of dry lemon extract on some biochemical parameters and histological changes on kidneys of male Wister Lewis rats after being found to be moldy and having residues of citrinin mycotoxin. Fifty inbred weaned white male Wistar Lewis rats were divided randomly into 5 groups (10 rats each) control group was daily gavaged with distilled water. The four treated groups were daily gavaged with a soup lemon extract (2ml/kg B.W) for 2 weeks (T1), double the dose (T2), triple the dose (T3). Group T4 was gavaged (2ml/kg B.W) of yellow lemon soup for 2 weeks. Sera from all groups were collected to measure several biochemical indicators to assess kidney function, such as urea (BUN) and creatinine (SCr). Serum BUN increased significantly in all treated groups as compared to control. Also, serum SCr increased significantly in all treated groups as compared to the control. On the other hand, total antioxidant concentration was significantly lower in all treated groups as compared to the control. However, alpha fetoprotein and carcinoembrionic antigen remained unchanged while pyruvate kinase isoenzyme M2 was decreased significantly. Histopathological changes of rat kidney revealed tubular degenerative changes in (T3) which explain biochemical changes. In conclusion, the uses of dry lemon as a traditional food supplement in the Gulf region may pose some risk of food poisoning due to the presence of citrinin. 
Supervisor : Dr. Ahmed N. Abo-Khatwa 
Thesis Type : Master Thesis 
Publishing Year : 1431 AH
2010 AD 
Co-Supervisor : Dr. Safaa Y. Qusti 
Added Date : Saturday, December 4, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
إيمان عبد العزيز المهينيAl-Muhaini, Eman AbdulazizResearcherMaster 

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