Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Vitamin-D status and determinants of serum 25-hydroxyvitamin D levels in healthy Saudi men > 50 years of age الحالة التغذوية لفيتامين – د ومحددات مستوى 25- هيدروكسي فيتامين – د في دم الرجال السعوديين (فوق الخمسين عام). |
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Subject |
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أمراض الغدد الصماء |
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Document Language |
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English |
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Abstract |
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Vitamin-D status and determinants of serum 25-hydroxyvitamin D levels in healthy Saudi men > 50 years of age
Ardawi, MSM1,2 ; Bahksh TM1,3 ; Qari, MH1,4 ; Maimani AA1,5. Center of Excellence for Osteoporosis Research1 and Departments of Clinical Biochemistry2, Surgery3, Haematology4 and Radiology5, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Background: Few studies exist on vitamin-D status among healthy Saudi men > 50 years of age and no information is available on the possible determinants of serum 25(OH)D levels in such men.
Aims: To determine vitamin-D status and the various determinants of serum 25(OH)D in relation to intact-PTH, bone turnover markers (BTMs) and bone mineral density (BMD) among healthy Saudi men > 50 years of age.
Subjects and Methods: A total number of 560 healthy Saudi men (age: > 50 years) living in the Jeddah area were randomly selected and studied. Anthropometric parameters, socioeconomic status, sun exposure index together with serum levels of 25(OH)D, intact-PTH, minerals, creatinine, albumin and biochemical BTMs were measured. BMD was measured by a dual energy X-ray absorptiometry.
Results: About 15.5% of all men exhibited severe vitamin-D deficiency (serum 25(OH)D < 12.5 nmol/L) and 69.3% of exhibited mild vitamin-D deficiency (serum 25(OH)D < 50.0 nmol/L) with only 12.7% of all men were considered with adequate vitamin D status (serum 25(OH)D > 75 nmol/L). Increased serum intact-PTH ( > 7.0 pmol/L) were evident in 19.1% in men with serum 25(OH)D < 50 nmol/L. Serum 25(OH)D showed significant inverse correlations with serum intact-PTH (r = -0.326; P < 0.001) and was lower (P < 0.001) and intact-PTH higher (P < 0.001) in the upper quintiles of BMI and WHR. Multiple linear regression analysis showed that vitamin-D supplementation, BMI, sun exposure index < 0.63, high WHR and dietary calcium intake were independent positive predictors of serum 25(OH)D values (R2 = 0.29).
Conclusions: Vitamin-D deficiency is highly prevalent among healthy Saudi men > 50 years of age and largely attributed to modifiable risk factors such as vitamin-D supplementation, obesity, exposure to sunlight, and dietary calcium intake. |
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ISSN |
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656767 |
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Journal Name |
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Osteoporosis International |
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Volume |
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5 |
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Issue Number |
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7 |
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Publishing Year |
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1430 AH
2009 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, August 1, 2010 |
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Researchers
| محمد صالح العرضاوي | Ardawi, Mohammed Saleh | Investigator | Doctorate | ardawims@yahoo.com |
| طلال محمد بخش | Bahksh, Talal Mohammed | Researcher | Doctorate | |
| محمد حسن قاري | Qari, Mohammed Hassan | Researcher | Doctorate | |
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