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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Glial intranuclear inclusion bodies in a patient with Alzheimer's disease.
Glial intranuclear inclusion bodies in a patient with Alzheimer's disease.
Document Language
:
English
Abstract
:
We report a case of dementia in an elderly woman with the pathological findings of Alzheimer's disease and numerous intranuclear inclusions in astrocytes and occasionally in neurons. These inclusions were seen in the cerebral cortex, limbic areas, basal ganglia, thalamus, brain stem and cerebellum. They expressed ubiquitin and were ultrastructurally composed of haphazardly arranged straight filaments. The presence of similar intranuclear inclusions in previous cases of adult-onset dementia without other neuropathological changes suggests an important link between these kind of inclusions and dementia. To our knowledge, this type of intranuclear inclusions has not been previously described in association with Alzheimer pathology.
ISSN
:
10867805
Journal Name
:
Acta Neuropathol.
Volume
:
99
Issue Number
:
6
Publishing Year
:
2000 AH
2000 AD
Article Type
:
Article
Added Date
:
Sunday, April 11, 2010
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
جودة المغربي
Al-Maghrabi, Jaudah
Investigator
Doctorate
Files
File Name
Type
Description
26397.doc
doc
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