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Document Type |
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Article In Journal |
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Document Title |
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Diagnostic accuracy of a bedside qualitative immunochromatographic test for acute myocardial infarction. Diagnostic accuracy of a bedside qualitative immunochromatographic test for acute myocardial infarction. |
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Document Language |
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English |
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Abstract |
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Alhashemi JA.
Department of Anesthesia and Critical Care, King Abdulaziz University, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. jalhashemi@kau.edu.sa
Comment in:
• Am J Emerg Med. 2009 Jan;27(1):116; author reply 116-7.
OBJECTIVE: To evaluate the diagnostic efficacy of a bedside immunochromatographic test (CardioDetect) that identifies human heart-type fatty acid-binding protein in whole blood. METHODS: Sixty-four patients with chest pain had CardioDetect test performed together with serial determination of serum troponin I (TnI) and creatine kinase (CK). CardioDetect results were interpreted twice, 24 hours apart, by 3 independent observers who were blinded to patients' clinical and laboratory data. Acute myocardial infarction was diagnosed by a physician blinded to the results of the CardioDetect test. Sensitivity, specificity, positive and negative predictive values, diagnostic accuracy, and receiver operating characteristic curves were determined for all tests at 4 predefined times. Intraobserver and interobserver reliabilities were determined. RESULTS: At less than 4 hours after chest pain, CardioDetect had a sensitivity and specificity of 62.5% and 100% compared with 50% and 80% for TnI and 37.5% and 80% for CK, respectively. At more than 4 hours but 12 hours or less in duration, the sensitivity of CardioDetect and TnI was 100%, whereas that of CK was 85.7%. Intraobserver agreement and interobserver reliability were high for CardioDetect (kappa >0.80 [P < .0001] and intraclass correlation coefficient, >0.90, respectively). CONCLUSION: CardioDetect was a reliable point-of-care test for the early diagnosis (<12 hours) of acute myocardial infarction in the ED.
PMID: 16490642 [PubMed - indexed for MEDLINE] |
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ISSN |
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16490642 |
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Journal Name |
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Am J Emerg Med. |
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Volume |
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24 |
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Issue Number |
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2 |
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Publishing Year |
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2006 AH
2006 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, March 21, 2010 |
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Researchers
| جمال الهاشمي | Alhashemi, Jamal | Researcher | Doctorate | |
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