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Document Type |
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Article In Journal |
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Document Title |
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Topiramate for The Treatment of Intractable Childhood Epilepsy. علاج التوبيريميت لعلاج الصرع المستعصى لدى الأطفال |
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Document Language |
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English |
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Abstract |
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Objectives: Topiramate (TPM) is a new antiepileptic drug (AED), which has a wide spectrum of activities suggesting a potentially valuable therapeutic profile. Our objective is to report our experience in treating children with intractable epilepsy. Methods: Prospective, open label, add on trial of TPM in treating consecutive children with intractable epilepsy (defined as recurrent seizures after at least 3 antiepileptic medication trials) seen between May 1, 1999 to April 28, 2002 at King Faisal Specialist Hospital and Research center and King Abdulaziz University Hospital in Jeddah. Follow up by two pediatric neurologists was performed. Therapeutic response was recorded as complete (no seizures), Good (>50% seizure reduction), fair (<50% seizure reduction), or none. Results: 62 children (36 males - 26 females) aged 2 months-16 years (mean 6 y) were treated with TPM and followed for up to 3 years (mean 15 months). Most children (55%) had daily seizures and were tried on multiple antiepileptic drugs (mean 4.6). Nineteen (31%) children had Lennox-Gastaut Syndrome. After the introduction of TPM, 21 (34%) became completely seizure free and 24 (39%) had >50% seizure reduction. Children with daily seizure were reduced from 55% before TPM to 13% on TPM (p=0.0007). Side effects were reported in 21 (34%) in the form of decreased appetite, weight loss, and sedation. The majority were transient, however, TPM had to be withdrawn in seven (11%) children because of progressive weight loss or seizure worsening. Follow-up renal ultrasound was performed on 34 (55%) children and was always normal. Conclusions: Topiramate is a very effective antiepileptic drug with broad spectrum of antiepileptic activities. Most side effects were transient, however, careful monitoring of the body weight is recommended. |
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ISSN |
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0940-5429 |
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Journal Name |
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Neurosciences Journal |
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Volume |
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4 |
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Issue Number |
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8 |
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Publishing Year |
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2003 AH
2003 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, March 13, 2010 |
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Researchers
| محمد جان | jan, Mohammed | Researcher | Doctorate | |
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