Document Details

Document Type : Article In Journal 
Document Title :
A prospective study of congenital malformations among liveborn neonates at a University Hospital in Western Saudi Arabia
دراسة مستقبلية للعيوب الخلقية عند الأطفال حديثي الولادة في جامعة الملك عبد العزيز بجدة المملكة العربية السعودية
 
Subject : Genetic disorders 
Document Language : English 
Abstract : Objective: To estimate the incidence of major and minor congenital malformations among liveborn infants at King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Estimation of risk factors were also evaluated. Methods: Between March 2004 and May 2005, a total of 5356 babies born at King Abdulaziz University Hospital, were enrolled in this study for malformations. Details of cases were recorded after parents' interviews, clinical, radiological, and laboratory evaluations. Results: One hundred and forty-seven (27.06/1000 livebirth) and 13 (2.39/1000 birth) stillbirth had congenital anomalies. In all livebirth, incidences of major anomalies were 93.9% and minor were 6.1%. Mothers of 95.9% with congenital malformation were healthy, 3.4% were diabetic and 0.7% had cardiac malfomation. In 38.8% of cases parents were consanguineous. Among the liveborn births, the most common system involved was cardiovascular (7.1/1000), followed by musculoskeletal/limb (4.1/1000), external genitalia (2.8/1000), urinary (2.6/1000), multiple chromosomal (2.2/1000), orofacial (1.9/1000), central nervous system (1.9/1000), skin (1.7/1000), multiple single gene (1.3/1000), multiple sequence (0.75/1000), eyes (0.56/1000), unclassified (0.19/1000), musculoskeletal/abdominal (0.19/1000), endocrine (0.19/1000). Conclusion: High incidence of major malformation in Jeddah. Importance of Genetic Counseling is revealed in our study since more than three quarters of mothers were under 36 years, and may well plan future pregnancies. 
ISSN : 0379-5284 
Journal Name : Saudi Medical Journal 
Volume : 28 
Issue Number : 9 
Publishing Year : 1427 AH
2007 AD 
Article Type : Article 
Added Date : Friday, February 12, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
ناديا فداFida, Nadia ResearcherDoctorate 
جمانة يوسف الأعمىAL- Aama, Jumana YResearcherDoctoratejalama@kau.edu.sa
وفاء نيكولاسNichols, Wafaa ResearcherDoctorate 
محمد القحطانيAlqahtani, القحطاني ResearcherMaster 

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