تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration
Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration
 
لغة الوثيقة : الانجليزية 
المستخلص : Musculoskeletal disorders represent a major cause of disability and morbidity globally and result in enormous costs for health and social care systems. Development of cell-based therapies is rapidly proliferating in a number of disease areas, including musculoskeletal disorders. Novel biological therapies that can effectively treat joint and spine degeneration are high priorities in regenerative medicine. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show considerable promise for use in cartilage and intervertebral disc (IVD) repair. This review article focuses on stem cell-based therapeutics for cartilage and IVD repair in the context of the rising global burden of musculoskeletal disorders. We discuss the biology MSCs and chondroprogenitor cells and specifically focus on umbilical cord/Wharton's jelly derived MSCs and examine their potential for regenerative applications. We also summarize key components of the molecular machinery and signaling pathways responsible for the control of chondrogenesis and explore biomimetic scaffolds and biomaterials for articular cartilage and IVD regeneration. This review explores the exciting opportunities afforded by MSCs and discusses the challenges associated with cartilage and IVD repair and regeneration. There are still many technical challenges associated with isolating, expanding, differentiating, and pre-conditioning MSCs for subsequent implantation into degenerate joints and the spine. However, the prospect of combining biomaterials and cell-based therapies that incorporate chondrocytes, chondroprogenitors and MSCs leads to the optimistic view that interdisciplinary approaches will lead to significant breakthroughs in regenerating musculoskeletal tissues, such as the joint and the spine in the near future. 
ردمد : 1095-9130 
اسم الدورية : Methods 
المجلد : 99 
العدد : 1 
سنة النشر : 1436 هـ
2015 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, April 27, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Stephen M. RichardsonRichardson, Stephen M.باحث رئيسي s.richardson@manchester.ac.uk
Gauthaman KalamegamKalamegam, Gauthaman باحث مشارك kgauthaman@kau.edu.sa
Peter N. PushparajPushparaj, Peter N.باحث مشارك peter.n.pushparaj@gmail.com
Csaba MattaMatta, Csaba باحث مشارك c.matta@surrey.ac.uk
Adnan MemicMemic, Adnan باحث مشارك amemic@gmail.com
Ali KhademhosseiniKhademhosseini, Ali باحث مشارك alik@rics.bwh.harvard.edu
Reza MobasheriMobasheri, Reza باحث مشارك reza.mobasheri@imperial.nhs.uk
Fabian L. PolettiPoletti, Fabian L.باحث مشارك Fabian.poletti@imperial.nhs.uk
Judith A. HoylandHoyland, Judith A.باحث مشارك judith.a.hoyland@manchester.ac.uk
Ali MobasheriMobasheri, Ali باحث مشارك a.mobasheri@surrey.ac.uk

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اسم الملفالنوعالوصف
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