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نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences.
Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences.
 
لغة الوثيقة : الانجليزية 
المستخلص : As space travel is expanding to include private tourism and travel beyond low-Earth orbit, so is the risk of exposure to space radiation. Galactic cosmic rays and solar particle events have the potential to expose space travelers to significant doses of radiation that can lead to increased cancer risk and other adverse health consequences. Metabolomics has the potential to assess an individual's risk by exploring the metabolic perturbations in a biofluid or tissue. In this study, C57BL/6 mice were exposed to 0.5 and 2 Gy of 1 GeV/nucleon of protons and the levels of metabolites were evaluated in urine at 4 h after radiation exposure through liquid chromatography coupled to time-of-flight mass spectrometry. Significant differences were identified in metabolites that map to the tricarboxylic acid (TCA) cycle and fatty acid metabolism, suggesting that energy metabolism is severely impacted after exposure to protons. Additionally, various pathways of amino acid metabolism (tryptophan, tyrosine, arginine and proline and phenylalanine) were affected with potential implications for DNA damage repair and cognitive impairment. Finally, presence of products of purine and pyrimidine metabolism points to direct DNA damage or increased apoptosis. Comparison of these metabolomic data to previously published data from our laboratory with gamma radiation strongly suggests a more pronounced effect on metabolism with protons. This is the first metabolomics study with space radiation in an easily accessible biofluid such as urine that further investigates and exemplifies the biological differences at early time points after exposure to different radiation qualities. 
ردمد : 0033-7587 
اسم الدورية : Radiation research 
المجلد : 183 
العدد : 4 
سنة النشر : 1436 هـ
2015 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, April 24, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Evagelia C. LaiakisLaiakis, Evagelia C.باحث رئيسي  
Daniela TraniTrani, Daniela باحث مشارك  
Bo-Hyun MoonMoon, Bo-Hyun باحث مشارك  
Steven J. StrawnStrawn, Steven J.باحث مشارك  
Albert J. Fornace JrFornace Jr, Albert J.باحث مشارك  

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