تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer
Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer
 
لغة الوثيقة : الانجليزية 
المستخلص : Carcinogenesis is an adaptive process between nascent tumor cells and their microenvironment, including the modification of inflammatory responses from antitumorigenic to protumorigenic. Radiation exposure can stimulate inflammatory responses that inhibit or promote carcinogenesis. The purpose of this study is to determine the impact of radiation exposure on lung cancer progression in vivo and assess the relevance of this knowledge to human carcinogenesis. EXPERIMENTAL DESIGN: K-ras(LA1) mice were irradiated with various doses and dose regimens and then monitored until death. Microarray analyses were performed using Illumina BeadChips on whole lung tissue 70 days after irradiation with a fractionated or acute dose of radiation and compared with age-matched unirradiated controls. Unique group classifiers were derived by comparative genomic analysis of three experimental cohorts. Survival analyses were performed using principal component analysis and k-means clustering on three lung adenocarcinoma, three breast adenocarcinoma, and two lung squamous carcinoma annotated microarray datasets. RESULTS: Radiation exposure accelerates lung cancer progression in the K-ras(LA1) lung cancer mouse model with dose fractionation being more permissive for cancer progression. A nonrandom inflammatory signature associated with this progression was elicited from whole lung tissue containing only benign lesions and predicts human lung and breast cancer patient survival across multiple datasets. Immunohistochemical analyses suggest that tumor cells drive predictive signature. CONCLUSIONS: These results demonstrate that radiation exposure can cooperate with benign lesions in a transgenic model of cancer by affecting inflammatory pathways, and that clinically relevant similarities exist between human lung and breast carcinogenesis. 
ردمد : 1078-0432 
اسم الدورية : Clinical Cancer Research 
المجلد : 20 
العدد : 6 
سنة النشر : 1435 هـ
2014 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Wednesday, March 9, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Oliver DelgadoDelgado, Oliver باحث رئيسي  
Kimberly G BattenBatten, Kimberly G باحث مشارك  
James A RichardsonRichardson, James A باحث  
Xian-Jin XieXie, Xian-Jin باحث مشارك  
Adi F GazdarGazdar, Adi F باحث  
Aadil A KaisaniKaisani, Aadil A باحث  
Luc GirardGirard, Luc باحث مشارك  
Carmen BehrensBehrens, Carmen باحث مشارك  
Milind SuraokarSuraokar, Milind باحث مشارك  
Gail FascianiFasciani, Gail باحث مشارك  
Jerry W ShayShay, Jerry W باحث  

الملفات

اسم الملفالنوعالوصف
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