تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
 
لغة الوثيقة : الانجليزية 
المستخلص : Study of heavy ion radiation-induced effects on mice could provide insight into the human health risks of space radiation exposure. The purpose of the present study is to assess the relative biological effectiveness (RBE) of (12)C and (28)Si ion radiation, which has not been reported previously in the literature. Female C57BL/6J mice (n = 15) were irradiated using 4-8 Gy of (28)Si (300 MeV/nucleon energy; LET 70 keV/μm) and 5-8 Gy of (12)C (290 MeV/nucleon energy; LET 13 keV/μm) ions. Post-exposure, mice were monitored regularly, and their survival observed for 30 days. The LD(50/30) dose (the dose at which 50 % lethality occurred by 30-day post-exposure) was calculated from the survival curve and was used to determine the RBE of (28)Si and (12)C in relation to γ radiation. The LD(50/30) for (28)Si and (12)C ion is 5.17 and 7.34 Gy, respectively, and the RBE in relation to γ radiation (LD(50/30)-7.25 Gy) is 1.4 for (28)Si and 0.99 for (12)C. Determination of RBE of (28)Si and (12)C for survival in mice is not only important for space radiation risk estimate studies, but it also has implications for HZE radiation in cancer therapy. 
ردمد : 0301-634X 
اسم الدورية : Radiation and environmental biophysics 
المجلد : 51 
العدد : 3 
سنة النشر : 1433 هـ
2012 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Tuesday, March 8, 2016 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Shubhankar SumanSuman, Shubhankar باحث رئيسي  
Kamal DattaDatta, Kamal باحث مشارك  
Daniela TraniTrani, Daniela باحث مشارك  
Evagelia C LaiakisLaiakis, Evagelia C باحث مشارك  
Steven J StrawnStrawn, Steven J باحث مشارك  
Albert J Fornace JrFornace Jr, Albert J باحث مشارك  

الملفات

اسم الملفالنوعالوصف
 38436.pdf pdf 

الرجوع إلى صفحة الأبحاث